Endocrine Abstracts

It was proved that zinc complexes of both metformin and phenformin could act as protease inhibitors with potency at therapeutic concentrations. Biguanide-metal complexes turned out to be more potent cysteine protease inhibitors than either the biguanide or zinc ions alone, i.e. showed synergistic effect. It can be assumed that changes in state of metabolism of zinc induced by ageing, genetic predispositions, accompanying diseases, and some other drugs administered to diabetic ...